Anti-Cyclin F CCNF Antibody
Boster Bio Anti-Cyclin F CCNF Antibody (Catalog # A06781) . Tested in WB, IHC applications. This antibody reacts with Human.
Product Specifications
Background
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.<br><br>Tsz Kan Fung, J. Biol. Chem., Sep 2002; 277: 35140 - 35149.<br>Michael T. Tetzlaff, Mol. Cell. Biol., Mar 2004; 24: 2487 - 2498.<br>Cain H. Yam, Mol. Cell. Biol., Jan 1999; 19: 635 - 645.<br>Michael T. Tetzlaff, PNAS, Mar 2004; 101: 3338 - 3345.
Synonyms
Cyclin-F; F-box only protein 1; CCNF; FBX1, FBXO1
Gene Name
CCNF
UniProt
P41002
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from human Cyclin F.
Clonality
Polyclonal
Tissue Specificity
Widely expressed. .
Applications
WB, IHC
Field of Research
Cell Biology, Cell Cycle
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Form
Liquid
Function
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. .
Molecular Weight
87640 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Cyclin-F
Subcellular Location
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus.
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