Anti-DNA-binding protein RFX2 RFX2 Antibody

Boster Bio Anti-DNA-binding protein RFX2 RFX2 Antibody (Catalog # A06709) . Tested in IHC applications. This antibody reacts with Human.

Product Specifications

Background

a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.<br><br>Reith W., Mol. Cell. Biol. 14:1230-1244(1994).<br>Sjoeblom T., Science 314:268-274(2006).

Synonyms

DNA-binding protein RFX2; Regulatory factor X 2; RFX2

Gene Name

RFX2

UniProt

P48378

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from internal of human RFX2.

Clonality

Polyclonal

Applications

IHC

Field of Research

Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Transcription

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Immunohistochemistry: 1:50~1:100

Form

Liquid

Function

Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity) . Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC (0-3N) RGYAAC-3' present on promoters (PubMed:10330134) . Probably activates transcription of the testis- specific histone gene HIST1H1T (By similarity) . .