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Anti-Cysteine protease ATG4A ATG4A Antibody

Boster Bio Anti-Cysteine protease ATG4A ATG4A Antibody (Catalog # A06539-1) . Tested in IHC, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.<br><br>Marino G., J. Biol. Chem. 278:3671-3678(2003).<br>Kabeya Y., J. Cell Sci. 117:2805-2812(2004).<br>Ross M.T., Nature 434:325-337(2005

Synonyms

Cysteine protease ATG4A;3.4.22.-; AUT-like 2 cysteine endopeptidase; Autophagin-2; Autophagy-related cysteine endopeptidase 2; Autophagy-related protein 4 homolog A; hAPG4A; ATG4A; APG4A, AUTL2

Gene Name

ATG4A

UniProt

Q8WYN0

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from C-terminal of human ATG4A.

Clonality

Polyclonal

Tissue Specificity

Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver. .

Applications

IHC, IF

Field of Research

Cancer, Cardiovascular, Cell Biology, Cell Death, Extracellular Matrix, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms. .

Molecular Weight

45378 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A06539-1

Product MSDS

https://www.bosterbio.com/msds?sku=A06539-1

Other Gene Names

Cysteine protease ATG4A

Subcellular Location

Cytoplasm .

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