Anti-MAN1B1/Ermani Antibody

Boster Bio Anti-MAN1B1/Ermani Antibody (Catalog # A06537) . Tested in WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1, 2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2.<br><br>Tremblay L.O., Glycobiology 9:1073-1078(1999) [PubMed: 10521544].<br>Gonzalez D.S., J. Biol. Chem. 274:21375-21386(1999) [PubMed: 10409699].<br>Clark H.F., Genome Res. 13:2265-2270(2003) [PubMed: 12975309].

Synonyms

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase;3.2.1.113 ; ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; Man9GlcNAc2-specific-processing alpha-mannosidase; Mannosidase alpha class 1B member 1; MAN1B1; UNQ747/PRO1477

Gene Name

MAN1B1

UniProt

Q9UKM7

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from internal of human MAN1B1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. .

Applications

Field of Research

Organelles, Subcellular Markers, Tags & Cell Markers

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Western blotting: 1:500~1:3000

Form

Liquid

Function

Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man (9) GlcNAc (2) to produce Man (8) GlcNAc (2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man (5-6) GlcNAc (2) . .