Anti-USP30 Antibody
Boster Bio Anti-USP30 Antibody catalog # A06403-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Ubiquitin carboxyl-terminal hydrolase 30;3.4.19.12 ; Deubiquitinating enzyme 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30; Ub-specific protease 30; USP30
Gene Name
USP30
UniProt
Q70CQ3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human USP30. AA range:31-80
Clonality
Polyclonal
Tissue Specificity
Expressed in skeletal muscle, pancreas, liver and kidney. .
Applications
ELISA, WB
Purification
Immunogen affinity purified
Concentration
1 mg/ml
Form
Liquid
Function
Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2) : hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951) . Preferentially cleaves 'Lys-6'- and 'Lys-11'- linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951) . Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291) . Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity) . .
Molecular Weight
58503 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Ubiquitin carboxyl-terminal hydrolase 30
Subcellular Location
Mitochondrion outer membrane .
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