Anti-Homeobox protein SIX5 SIX5 Antibody

Boster Bio Anti-Homeobox protein SIX5 SIX5 Antibody (Catalog # A06210) . Tested in WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter By similarity. Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 By similarity.<br><br>Boucher C.A., Hum. Mol. Genet. 4:1919-1925(1995).<br>Grimwood J., Nature 428:529-535(2004).<br>The MGC Project Team; Genome Res. 14:2121-2127(2004).

Synonyms

Homeobox protein SIX5; DM locus-associated homeodomain protein; Sine oculis homeobox homolog 5; SIX5; DMAHP

Gene Name

SIX5

UniProt

Q8N196

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from internal of human SIX5.

Clonality

Polyclonal

Tissue Specificity

Expressed in adult but not in fetal eyes. Found in corneal epithelium and endothelium, lens epithelium, ciliary body epithelia, cellular layers of the retina and the sclera. .

Applications

Field of Research

Domain Families, Epigenetics and Nuclear Signaling, Transcription

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Western blotting: 1:500~1:3000

Form

Liquid

Function

Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'- TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity) . Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity) . .