Anti-MED24/Trap100 Antibody

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<br><br>Yuan C.-X., Proc. Natl. Acad. Sci. U.S.A. 95:7939-7944(1998).<br>Rachez C., Genes Dev. 12:1787-1800(1998).<br>Nagase T., DNA Res. 2:167-174(1995).

Mediator of RNA polymerase II transcription subunit 24; Activator-recruited cofactor 100 kDa component; ARC100; Cofactor required for Sp1 transcriptional activation subunit 4; CRSP complex subunit 4; Mediator complex subunit 24; Thyroid hormone receptor-associated protein 4; Thyroid hormone receptor-associated protein complex 100 kDa component; Trap100; hTRAP100; Vitamin D3 receptor-interacting protein complex 100 kDa component; DRIP100; MED24; ARC100, CRSP4, DRIP100, KIAA0130, THRAP4, TRAP100

Co-Activators/Co-Repressors, Co-Factors, Epigenetics and Nuclear Signaling, Mediator Complex, Nuclear Receptors, Nuclear Signaling Pathways, Transcription

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .