Anti-Abin-2 TNIP2 Antibody
Boster Bio Anti-Abin-2 TNIP2 Antibody catalog # A05716. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
TNFAIP3-interacting protein 2; A20-binding inhibitor of NF-kappa-B activation 2; ABIN-2; Fetal liver LKB1-interacting protein; TNIP2 ; ABIN2, FLIP1
Gene Name
TNIP2
UniProt
Q8NFZ5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide from human protein at AA range: 61-110
Tissue Specificity
Ubiquitously expressed in all tissues examined. .
Applications
IHC
Purification
Immunogen affinity purified
Dilution
IHC-P, 1:50-300
Form
Liquid
Function
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. .
Molecular Weight
48700 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
TNFAIP3-interacting protein 2
Subcellular Location
Cytoplasm . Nucleus .
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