Anti-TLK1 Antibody

Boster Bio Anti-TLK1 Antibody (Catalog # A05635-1) . Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.<br><br>Yamakawa A., Gene 202:193-201(1997).<br>Sillje H.H.W., EMBO J. 18:5691-5702(1999).<br>Cabaniols J.-P., Mol. Biol. Cell 10:4033-4041(1999).

Synonyms

Serine/threonine-protein kinase tousled-like 1;2.7.11.1; PKU-beta; Tousled-like kinase 1; TLK1; KIAA0137

Gene Name

TLK1

UniProt

Q9UKI8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from internal of human TLK1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined. .

Applications

Field of Research

Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Western blotting: 1:500~1:3000

Form

Liquid

Function

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. .