Anti-SLC9A3R2/Nherf 2 Antibody
Boster Bio Anti-SLC9A3R2/Nherf 2 Antibody (Catalog # A05624-1) . Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus.<br><br>Poulat F., J. Biol. Chem. 272:7167-7172(1997) [PubMed: 9054412].<br>Reczek D., J. Cell Biol. 139:169-179(1997) [PubMed: 9314537].<br>Yun C.H.C., Proc. Natl. Acad. Sci. U.S.A. 94:3010-3015(1997) [PubMed: 9096337].
Synonyms
Na (+) /H (+) exchange regulatory cofactor NHE-RF2; NHERF-2; NHE3 kinase A regulatory protein E3KARP; SRY-interacting protein 1; SIP-1; Sodium-hydrogen exchanger regulatory factor 2; Solute carrier family 9 isoform A3 regulatory factor 2; Tyrosine kinase activator protein 1; TKA-1; SLC9A3R2; NHERF2
Gene Name
SLC9A3R2
UniProt
Q15599
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from internal of human SLC9A3R2.
Clonality
Polyclonal
Tissue Specificity
Widely expressed. .
Applications
WB
Field of Research
Microfilaments, Plasma Membrane, Signal Transduction
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Dilution
Western blotting: 1:500~1:3000
Form
Liquid
Function
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453) . May also act as scaffold protein in the nucleus. .
Molecular Weight
37414 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Na (+) /H (+) exchange regulatory cofactor NHE-RF2
Subcellular Location
Endomembrane system ; Peripheral membrane protein . Nucleus . Apical cell membrane . Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity) . Nuclear, in a punctate pattern. .
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