Anti-SESN1/Pa26 Antibody

Boster Bio Anti-SESN1/Pa26 Antibody (Catalog# A05559-1) . Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

SESN1; PA26; SEST1; Sestrin-1; p53-regulated protein PA26

Gene Name

SESN1

UniProt

Q9Y6P5

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A peptide derived from human SESN1. Immunogen sequence location: 271 - 320

Clonality

Polyclonal

Tissue Specificity

Widely expressed.

Applications

WB, IHC-P, IF (paraffin), ELISA

Field of Research

Cell Biology, Metabolism, Obesity, Oxidative Stress, Pathways and Processes, Redox Metabolism

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471) . This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity) . May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085) . May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity) . Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503) . However, this could not be confirmed (By similarity) .