Anti-USP11 Antibody
Boster Bio Anti-USP11 Antibody catalog # A05225-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Ubiquitin carboxyl-terminal hydrolase 11;3.4.19.12 ; Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11; USP11; UHX1
Gene Name
USP11
UniProt
P51784
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human USP11.
Applications
WB
Purification
Immunogen affinity purified
Form
Liquid
Function
Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799) . Inhibits the degradation of target proteins by the proteasome (PubMed:12084015) . Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'- linked ubiquitin chains (in vitro) (PubMed:24724799) . Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889) . Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726) . .
Molecular Weight
109817 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Ubiquitin carboxyl-terminal hydrolase 11
Subcellular Location
Nucleus . Cytoplasm . Predominantly nuclear (PubMed:12084015, PubMed:15314155) . Associates with chromatin (PubMed:20233726) . .
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