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Anti-USP11 Antibody

Boster Bio Anti-USP11 Antibody catalog # A05225-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Ubiquitin carboxyl-terminal hydrolase 11;3.4.19.12 ; Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11; USP11; UHX1

Gene Name

USP11

UniProt

P51784

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from the Internal region of human USP11.

Applications

WB

Purification

Immunogen affinity purified

Form

Liquid

Function

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799) . Inhibits the degradation of target proteins by the proteasome (PubMed:12084015) . Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'- linked ubiquitin chains (in vitro) (PubMed:24724799) . Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889) . Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726) . .

Molecular Weight

109817 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Ubiquitin carboxyl-terminal hydrolase 11

Subcellular Location

Nucleus . Cytoplasm . Predominantly nuclear (PubMed:12084015, PubMed:15314155) . Associates with chromatin (PubMed:20233726) . .

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