Anti-IgD IGHD Antibody
Boster Bio Anti-IgD IGHD Antibody catalog # A05183. Tested in IHC applications. This antibody reacts with Human.
Product Specifications
Synonyms
Ig delta chain C region; IGHD
Gene Name
IGHD
UniProt
P01880
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide from human protein at AA range: 111-160
Applications
IHC
Purification
Immunogen affinity purified
Dilution
IHC-P, 1:50-300
Form
Liquid
Function
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD. .
Molecular Weight
42254 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Ig delta chain C region
Subcellular Location
Isoform 1: Secreted.
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