Anti-Kelch-like protein 3 KLHL3 Antibody
Boster Bio Anti-Kelch-like protein 3 KLHL3 Antibody (Catalog # A05117) . Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse.
Product Specifications
Background
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation.<br><br>Lai F., Genomics 66:65-75(2000).<br>Hirosawa M., DNA Res. 6:329-336(1999).<br>Ota T., Nat. Genet. 36:40-45(2004).
Synonyms
Kelch-like protein 3; KLHL3; KIAA1129
Gene Name
KLHL3
UniProt
Q9UH77
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from N-terminal of human KLHL3.
Clonality
Polyclonal
Tissue Specificity
Widely expressed. .
Applications
WB, IHC, IF
Field of Research
Cell Biology
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Form
Liquid
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR (KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation. .
Molecular Weight
64970 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Kelch-like protein 3
Subcellular Location
Cytoplasm, cytoskeleton . Cytoplasm, cytosol .
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