Anti-LILRB4/Gp49 Antibody

Boster Bio Anti-LILRB4/Gp49 Antibody (Catalog # A04924) . Tested in IF applications. This antibody reacts with Human.

Product Specifications

Background

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<br><br>Arm J.P., J. Immunol. 159:2342-2349(1997). <br>Borges L., J. Immunol. 159:5192-5196(1997). <br>Liu W.R., Immunogenetics 51:659-669(2000).

Synonyms

Leukocyte immunoglobulin-like receptor subfamily B member 4; CD85 antigen-like family member K; Immunoglobulin-like transcript 3; ILT-3; Leukocyte immunoglobulin-like receptor 5; LIR-5; Monocyte inhibitory receptor HM18; CD85k; LILRB4; ILT3, LIR5

Gene Name

LILRB4

UniProt

Q8NHJ6

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from internal of human LILRB4.

Clonality

Polyclonal

Tissue Specificity

Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. .

Applications

Field of Research

NFKB Pathway, Nuclear Signaling Pathways, Receptors

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Immunofluorescence: 1:100~1:500

Form

Liquid

Function

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. .