Anti-Nephrocystin-4 NPHP4 Antibody

Boster Bio Anti-Nephrocystin-4 NPHP4 Antibody (Catalog # A04919) . Tested in IHC applications. This antibody reacts with Human.

Product Specifications

Background

Involved in the organization of apical junctions in kidney cells together with NPHP1 and RPGRIP1L/NPHP8 By similarity. Does not seem to be strictly required for ciliogenesis By similarity.<br><br>Mollet G., Nat. Genet. 32:300-305(2002).<br>Mollet G., Nat. Genet. 32:459-459(2002).<br>Otto E., Am. J. Hum. Genet. 71:1161-1167(2002).

Synonyms

Nephrocystin-4; Nephroretinin; NPHP4; KIAA0673

Gene Name

NPHP4

UniProt

O75161

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from internal of human NPHP4.

Clonality

Polyclonal

Tissue Specificity

Expressed in kidney, skeletal muscle, heart and liver, and to a lesser extent in brain and lung. .

Applications

IHC

Field of Research

Cell Adhesion, Cell Biology, Cytoskeleton/ECM, Signal Transduction, Tight Junctions

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Immunohistochemistry: 1:50~1:100

Form

Liquid

Function

Involved in the organization of apical junctions in kidney cells together with NPHP1 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. .

Molecular Weight

157598 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Nephrocystin-4

Subcellular Location

Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, tight junction. In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions.