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Anti-AOS1 SAE1 Antibody

Boster Bio Anti-AOS1 SAE1 Antibody (Catalog # A04753-2) . Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.<br><br>Yoshiaki Azuma, FASEB J, Jun 2001; 10.1096.<br>Walter Makous, Invest. Ophthalmol. Vis. Sci., Sep 2006; 47: 4160 - 4167. <br>Hsin-Pei Shih, J. Cell Sci., Mar 2002; 115: 1259. <br>Thomas Buschmann, J. Biol. Chem., Oct 2001; 276: 40389 - 40395.

Synonyms

SUMO-activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A; SUMO-activating enzyme subunit 1, N-terminally processed; SAE1; AOS1, SUA1, UBLE1A

Gene Name

SAE1

UniProt

Q9UBE0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from Internal of human AOS1.

Clonality

Polyclonal

Tissue Specificity

Expression level increases during S phase and drops in G2 phase (at protein level) . .

Applications

WB, IF

Field of Research

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ub-Like Proteins

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. .

Molecular Weight

38450 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

SUMO-activating enzyme subunit 1

Subcellular Location

Nucleus .

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