Anti-Forkhead box protein D3 FOXD3 Antibody

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.<br><br>Gregory S.G., Nature 441:315-321(2006).<br>Guo Y., Proc. Natl. Acad. Sci. U.S.A. 99:3663-3667(2002).<br>Ramsey H.C., Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.

Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. .

Cancer, Developmental Biology, Domain Families, Embryogenesis, Embryonic Stem Cells, Epigenetics and Nuclear Signaling, Forkhead Box, Intracellular, Metabolism, Neural Stem Cells, Neurogenesis, Neurology Process, Neuroscience, Stem Cells, Surface Molecules, Transcription

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. .