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Anti-IFIT2 Antibody

Boster Bio Anti-IFIT2 Antibody (Catalog# A04428) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Synonyms

Interferon-induced protein with tetratricopeptide repeats 2; IFIT-2; ISG-54 K; Interferon-induced 54 kDa protein; IFI-54K; P54; IFIT2; CIG-42, G10P2, IFI54, ISG54

Gene Name

IFIT2

UniProt

P09913

Host

Rabbit

Reactivity

Human

Immunogen

A partial length recombinant IFIT2 protein (amino acids 150-370)

Clonality

Polyclonal

Applications

WB

Field of Research

Cytoskeleton, Cytoskeleton/ECM, Immunology, Innate Immunity, Macrophage/Inflammation, Microtubules, Signal Transduction, Tubulin

Purification

Protein A Chromatography

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

Western blot: 2-4 µg/ml

Form

Liquid

Function

IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism) . Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. .

Molecular Weight

54632 MW

Shipping Conditions

Available

Storage Conditions

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Interferon-induced protein with tetratricopeptide repeats 2

Subcellular Location

Cytoplasm. Endoplasmic reticulum.

Protein Name

Interferon-induced protein with tetratricopeptide repeats 2

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