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Anti-Twist2 Antibody

Boster Bio Anti-Twist2 Antibody (Catalog # A04422) . Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.

Synonyms

Twist-related protein 2; Class A basic helix-loop-helix protein 39; bHLHa39; Dermis-expressed protein 1; Dermo-1; TWIST2; BHLHA39, DERMO1

Gene Name

TWIST2

UniProt

Q8WVJ9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide sequence around aa.26~30 (P-K-R-F-G) derived from Human Twist2.

Clonality

Polyclonal

Tissue Specificity

In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules. .

Applications

WB

Field of Research

Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Mesenchymal Stem Cells, Stem Cells, Transcription, Transcription Factors

Purification

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/ml

Form

Liquid

Function

Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity) . Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. .

Molecular Weight

18124 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Twist-related protein 2

Subcellular Location

Nucleus . Cytoplasm . Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.

Frequently Asked Questions

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