Anti-PA28 gamma PSME3 Monoclonal Antibody
Boster Bio Anti-PA28 gamma PSME3 Monoclonal Antibody catalog # A04375. Tested in WB applications. This antibody reacts with Human, Mouse, Pig.
Product Specifications
Synonyms
Proteasome activator complex subunit 3;11S regulator complex subunit gamma; REG-gamma; Activator of multicatalytic protease subunit 3; Ki nuclear autoantigen; Proteasome activator 28 subunit gamma; PA28g; PA28gamma; PSME3
Gene Name
PSME3
UniProt
P61289
Host
Mouse
Reactivity
Human, Mouse, , Pig
Immunogen
Purified recombinant human PA28γ protein fragments expressed in E.coli.
Clonality
Monoclonal
Applications
WB
Purification
Protein A purified
Sensitivity
>5000 cells
Dilution
WB, 1:1000-1:2000
Form
Liquid
Function
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978) . .
Molecular Weight
29506 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A04375
Product MSDS
https://www.bosterbio.com/msds?sku=A04375
Other Gene Names
Proteasome activator complex subunit 3
Subcellular Location
Nucleus . Cytoplasm . Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. .
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
