Anti-EPHB6/Eph Receptor B6 Antibody
Boster Bio Anti-EPHB6/Eph Receptor B6 Antibody (Catalog # A04270) . Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.<br><br>atsuoka H., Biochem. Biophys. Res. Commun. 235:487-492(1997).<br>Hillier L.W., Nature 424:157-164(2003).<br>Zhang Z., Protein Sci. 13:2819-2824(2004).
Synonyms
Ephrin type-B receptor 6; HEP; Tyrosine-protein kinase-defective receptor EPH-6; EPHB6
Gene Name
EPHB6
UniProt
O15197
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from internal of human EPHB6.
Clonality
Polyclonal
Tissue Specificity
Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level) . Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues. .
Applications
WB, IHC, IF
Field of Research
Axonal Guidance Proteins, Cell Type Marker, Growth and Development, Intracellular Signaling, Kinases, Neurology Process, Neuron Marker, Neuroscience, Neurotransmission, Receptors / Channels
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Form
Liquid
Function
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. .
Molecular Weight
110700 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Ephrin type-B receptor 6
Subcellular Location
Membrane; Single-pass type I membrane protein.
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