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Anti-EPHB6/Eph Receptor B6 Antibody

Boster Bio Anti-EPHB6/Eph Receptor B6 Antibody (Catalog # A04270) . Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.<br><br>atsuoka H., Biochem. Biophys. Res. Commun. 235:487-492(1997).<br>Hillier L.W., Nature 424:157-164(2003).<br>Zhang Z., Protein Sci. 13:2819-2824(2004).

Synonyms

Ephrin type-B receptor 6; HEP; Tyrosine-protein kinase-defective receptor EPH-6; EPHB6

Gene Name

EPHB6

UniProt

O15197

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from internal of human EPHB6.

Clonality

Polyclonal

Tissue Specificity

Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level) . Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues. .

Applications

WB, IHC, IF

Field of Research

Axonal Guidance Proteins, Cell Type Marker, Growth and Development, Intracellular Signaling, Kinases, Neurology Process, Neuron Marker, Neuroscience, Neurotransmission, Receptors / Channels

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. .

Molecular Weight

110700 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A04270

Product MSDS

https://www.bosterbio.com/msds?sku=A04270

Other Gene Names

Ephrin type-B receptor 6

Subcellular Location

Membrane; Single-pass type I membrane protein.

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