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Anti-LTK Antibody

Boster Bio Anti-LTK Antibody (Catalog # A04217) . Tested in WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.<br><br>Toyoshima H., Proc. Natl. Acad. Sci. U.S.A. 90:5404-5408(1993).<br>Krolewski J.J., EMBO J. 10:2911-2919(1991).<br>Maru Y., Oncogene Res. 5:199-204(1990).

Synonyms

Leukocyte tyrosine kinase receptor;2.7.10.1; Protein tyrosine kinase 1; LTK; TYK1

Gene Name

LTK

UniProt

P29376

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from internal of human LTK.

Clonality

Polyclonal

Tissue Specificity

Expressed in non-hematopoietic cell lines and T- and B-cell lines. .

Applications

WB

Field of Research

Energy Metabolism, Energy Transfer Pathways, Growth Factors/Hormones, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Tyrosine Kinases

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Western blotting: 1:500~1:3000

Form

Liquid

Function

Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. .

Molecular Weight

91681 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A04217

Product MSDS

https://www.bosterbio.com/msds?sku=A04217

Other Gene Names

Leukocyte tyrosine kinase receptor

Subcellular Location

Membrane; Single-pass type I membrane protein.

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