Anti-JHD3B KDM4B Antibody
Boster Bio Anti-JHD3B KDM4B Antibody (Catalog # A04127) . Tested in IHC applications. This antibody reacts with Human.
Product Specifications
Background
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.<br><br>Nagase T., DNA Res. 5:355-364(1998).<br>Nakajima D., DNA Res. 9:99-106(2002).<br>Grimwood J., Nature 428:529-535(2004).
Synonyms
Lysine-specific demethylase 4B;1.14.11.-; JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B; KDM4B; JHDM3B, JMJD2B, KIAA0876
Gene Name
KDM4B
UniProt
O94953
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from C-terminal of human JHD3B.
Clonality
Polyclonal
Applications
IHC
Field of Research
Chromatin Modifying Enzymes, Co-Activators/Co-Repressors, Epigenetics and Nuclear Signaling, Nuclear Receptors, Nuclear Signaling Pathways
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1:50~1:100
Form
Liquid
Function
Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. .
Molecular Weight
121897 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Lysine-specific demethylase 4B
Subcellular Location
Nucleus .
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