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Anti-MST-3 Antibody

Boster Bio Anti-MST-3 Antibody catalog # A04112-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Serine/threonine-protein kinase 24;2.7.11.1; Mammalian STE20-like protein kinase 3; MST-3; STE20-like kinase MST3; Serine/threonine-protein kinase 24 36 kDa subunit; Mammalian STE20-like protein kinase 3 N-terminal; MST3/N; Serine/threonine-protein kinase 24 12 kDa subunit; Mammalian STE20-like protein kinase 3 C-terminal; MST3/C; STK24; MST3, STK3

Gene Name

STK24

UniProt

Q9Y6E0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human STK24. AA range:319-368

Tissue Specificity

Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.

Applications

WB

Purification

Immunogen affinity purified

Sensitivity

<10pg/ml

Dilution

WB, 1:500-1:2000

Form

Liquid

Function

Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. .

Molecular Weight

49308 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Serine/threonine-protein kinase 24

Subcellular Location

Cytoplasm. Nucleus. Membrane. The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.

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