Anti-Cyclin-L1 CCNL1 Antibody

Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.<br><br>A. Hamid Boulares, J. Biol. Chem., Aug 1999; 274: 22932. <br>Alessandra Pagano, Am J Physiol Lung Cell Mol Physiol, Jun 2007; 10.1152.<br>Mi Young Kim, Genes & Dev., Sep 2005; 19: 1951 - 1967. <br>Silke S¨¹sse, Nucleic Acids Res., Feb 2004; 32: 669 - 680.

Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018) . Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906) . May play a role in the regulation of RNA polymerase II (pol II) . May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036) . .

Nucleus speckle . Nucleus, nucleoplasm . Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. .