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Anti-REST Antibody

Boster Bio Anti-REST Antibody (Catalog # A03852) . Tested in WB applications. This antibody reacts with Human.

Product Specifications

Background

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. <br><br>Chong J.A.et.al. (1995)Cell 80:949-957 <br>Schoenherr C.J.et.al.(1995)Science 267:1360-1363 <br>Scholl T.et.al.(1996)J. Immunol. 156:1448-1457 <br>Lunyak V.V.et.al. (2002)Science 298:1747-1752

Gene Name

REST

UniProt

Q13127

Host

Rabbit

Reactivity

Human

Immunogen

Peptide sequence around aa.873~877 (R-E-E-A-S) derived from Human REST.

Clonality

Polyclonal

Applications

WB

Field of Research

Co-Factors, Domain Families, Epigenetics and Nuclear Signaling, Neurogenesis, Neurology Process, Neuroscience, Transcription, Zinc Finger

Purification

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/ml

Form

Liquid

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

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