Anti-REST Antibody
Boster Bio Anti-REST Antibody (Catalog # A03852) . Tested in WB applications. This antibody reacts with Human.
Product Specifications
Background
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
<br><br>Chong J.A.et.al. (1995)Cell 80:949-957
<br>Schoenherr C.J.et.al.(1995)Science 267:1360-1363
<br>Scholl T.et.al.(1996)J. Immunol. 156:1448-1457
<br>Lunyak V.V.et.al. (2002)Science 298:1747-1752
Gene Name
REST
UniProt
Q13127
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around aa.873~877 (R-E-E-A-S) derived from Human REST.
Clonality
Polyclonal
Applications
WB
Field of Research
Co-Factors, Domain Families, Epigenetics and Nuclear Signaling, Neurogenesis, Neurology Process, Neuroscience, Transcription, Zinc Finger
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/ml
Form
Liquid
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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