Anti-BPTF/Falz Monoclonal Antibody
Boster Bio Anti-BPTF/Falz Monoclonal Antibody catalog # A03754. Tested in WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
Nucleosome-remodeling factor subunit BPTF; Bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen; BPTF; FAC1, FALZ
Gene Name
BPTF
UniProt
Q12830
Host
Mouse
Reactivity
Human
Immunogen
Purified recombinant fragment of human BPTF expressed in E. Coli.
Clonality
Monoclonal
Clone
Clone: 2F1
Tissue Specificity
Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level) . .
Applications
WB
Purification
Ascitic fluid
Form
Liquid
Function
Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
Molecular Weight
338262 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Nucleosome-remodeling factor subunit BPTF
Subcellular Location
Cytoplasm. Nucleus. In brains of Alzheimer disease patients, present in a subset of amyloid- containing plaques.
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