Anti-Mnk2 MKNK2 Antibody
Boster Bio Anti-Mnk2 MKNK2 Antibody catalog # A03619. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
MAP kinase-interacting serine/threonine-protein kinase 2;2.7.11.1; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2; MKNK2; GPRK7, MNK2
Gene Name
MKNK2
UniProt
Q9HBH9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human Mnk2.
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1. .
Applications
WB
Purification
Immunogen affinity purified
Form
Liquid
Function
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As (2) O (3) -dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. .
Molecular Weight
51875 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
MAP kinase-interacting serine/threonine-protein kinase 2
Subcellular Location
Isoform 2: Nucleus, PML body.
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