Anti-ELOVL5 Antibody

Condensing enzyme that catalyzes the synthesis of monounsaturated and of polyunsaturated very long chain fatty acids Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA.<br><br>Leonard A.E., Biochem. J. 350:765-770(2000).<br>Suzuki T., Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.<br>Wiemann S., Genome Res. 11:422-435(2001).

Elongation of very long chain fatty acids protein 5 ;2.3.1.199 ;3-keto acyl-CoA synthase ELOVL5 ; ELOVL fatty acid elongase 5 ; ELOVL FA elongase 5 ; Fatty acid elongase 1; hELO1; Very long chain 3-ketoacyl-CoA synthase 5 ; Very long chain 3-oxoacyl-CoA synthase 5 ; ELOVL5 ; ELOVL2; PRO0530

Cardiovascular, Fatty Acid Oxidation, Fatty Acids, Lipid Metabolism, Lipids/Lipoproteins, Metabolism, Pathways and Processes, Redox Metabolism, Signal Transduction

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3 (n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. .

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell projection, dendrite . In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. .