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Anti-RBM5/Luca15 Antibody

Boster Bio Anti-RBM5/Luca15 Antibody (Catalog # A03559) . Tested in WB, IHC applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.<br><br>Bader S., Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.<br>Timmer T., Genomics 60:238-240(1999).<br>Oh J.J., Nucleic Acids Res. 27:4008-4017(1999).

Synonyms

RNA-binding protein 5; Protein G15; Putative tumor suppressor LUCA15; RNA-binding motif protein 5; Renal carcinoma antigen NY-REN-9; RBM5; H37, LUCA15

Gene Name

RBM5

UniProt

P52756

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from internal of human RBM5.

Clonality

Polyclonal

Tissue Specificity

Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.

Applications

WB, IHC

Field of Research

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling, Oncoproteins/Suppressors, Tumor Suppressors

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. .

Molecular Weight

92154 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A03559

Product MSDS

https://www.bosterbio.com/msds?sku=A03559

Other Gene Names

RNA-binding protein 5

Subcellular Location

Nucleus .

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