Anti-Dab1 (Ab-232) Antibody

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. <br><br>Kelian Chen, et, al. (2003) J. Cell Sci ; 117: 4527 - 4536. <br>Vera Strasser, et, al. (2004) Mol. Cell. Biol ; 24: 1378 - 1386. <br>Izhar Ben-Shlomo, et, al. (2003) Sci. STKE ; 2003: 9. <br>H. M. Kim, et, al. (2002) PNAS ; 99: 4020.

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.