What is the catalog number for Anti-TRIM24/Tif1 Alpha Antibody?

The catalog number for Anti-TRIM24/Tif1 Alpha Antibody is A03258-1.

Is Anti-TRIM24/Tif1 Alpha Antibody in stock?

Anti-TRIM24/Tif1 Alpha Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-TRIM24/Tif1 Alpha Antibody?

The safety data sheet for Anti-TRIM24/Tif1 Alpha Antibody is available here: https://www.bosterbio.com/msds?sku=A03258-1.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

Anti-TRIM24/Tif1 Alpha Antibody

Boster Bio Anti-TRIM24/Tif1 Alpha Antibody (Catalog # A03258-1) . Tested in WB, IHC applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes By similarity.<br><br>Thenot S., J. Biol. Chem. 272:12062-12068(1997).<br>Venturini L., Oncogene 18:1209-1217(1999).<br>Hellal-Levy C., Mol. Endocrinol. 14:1210-1221(2000).

Synonyms

Transcription intermediary factor 1-alpha; TIF1-alpha;6.3.2.-; E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; Tripartite motif-containing protein 24; TRIM24; RNF82, TIF1, TIF1A

Gene Name

TRIM24

UniProt

O15164

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from C-terminal of human TRIM24.

Clonality

Polyclonal

Applications

WB, IHC

Field of Research

Co-Activators/Co-Repressors, Epigenetics and Nuclear Signaling, Nuclear Hormone Receptors, Nuclear Receptors, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Transcription

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) . Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity) . .

Molecular Weight

116831 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Transcription intermediary factor 1-alpha

Subcellular Location

Nucleus . Cytoplasm . Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear.