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Anti-Thyroxine 5-deiodinase DIO3 Antibody

Boster Bio Anti-Thyroxine 5-deiodinase DIO3 Antibody catalog # A02903. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Thyroxine 5-deiodinase;1.21.99.3 ;5DIII; DIOIII; Type 3 DI; Type III iodothyronine deiodinase; DIO3; ITDI3, TXDI3

Gene Name

DIO3

UniProt

P55073

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human DIO3. AA range:17-66

Tissue Specificity

Expressed in placenta and several fetal tissues.

Applications

WB

Purification

Immunogen affinity purified

Form

Liquid

Function

Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine) . RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. .

Molecular Weight

33947 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Thyroxine 5-deiodinase

Subcellular Location

Cell membrane ; Single-pass type II membrane protein . Endosome membrane ; Single-pass type II membrane protein .

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