Anti-MRF2 ARID5B Antibody

Boster Bio Anti-MRF2 ARID5B Antibody (Catalog# A02880) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Synonyms

AT-rich interactive domain-containing protein 5B; ARID domain-containing protein 5B; MRF1-like protein; Modulator recognition factor 2; MRF-2; ARID5B; DESRT, MRF2

Gene Name

ARID5B

UniProt

Q14865

Host

Rabbit

Reactivity

Human

Immunogen

A partial length recombinant MRF2 protein (amino acids 430-621)

Clonality

Polyclonal

Tissue Specificity

Widely expressed, including in liver (at protein level) .

Applications

Field of Research

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling, Transcription, Transcription Factors

Purification

Protein A Chromatography

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

Western blot: 1-2 µg/ml

Form

Liquid

Function

Transcription coactivator that binds to the 5'-AATA[CT]- 3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2- ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. .

Molecular Weight

132375 MW

Shipping Conditions

Available

Storage Conditions

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

AT-rich interactive domain-containing protein 5B

Subcellular Location

Nucleus.

Protein Name

AT-rich interactive domain-containing protein 5B

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