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Anti-SmcX KDM5C Monoclonal Antibody

Boster Bio Anti-SmcX KDM5C Monoclonal Antibody catalog # A02849. Tested in IF, WB applications. This antibody reacts with Bovine, Dog, Human, Mouse, Rat.

Product Specifications

Synonyms

Lysine-specific demethylase 5C;1.14.11.-; Histone demethylase JARID1C; Jumonji/ARID domain-containing protein 1C; Protein SmcX; Protein Xe169; KDM5C; DXS1272E, JARID1C, SMCX, XE169

Gene Name

KDM5C

UniProt

P41229

Host

Mouse

Reactivity

Bovine, Dog, Human, Mouse, Rat

Immunogen

Purified recombinant human SmcX (C-terminus) protein fragments expressed in E.coli.

Clonality

Monoclonal

Tissue Specificity

Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. .

Applications

IF, WB

Purification

Affinity purification

Concentration

1 mg/ml

Form

Liquid

Function

Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity) . .

Molecular Weight

175720 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A02849

Product MSDS

https://www.bosterbio.com/msds?sku=A02849

Other Gene Names

Lysine-specific demethylase 5C

Subcellular Location

Nucleus .

Curated Selection

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