Anti-SmcX KDM5C Monoclonal Antibody
Boster Bio Anti-SmcX KDM5C Monoclonal Antibody catalog # A02849. Tested in IF, WB applications. This antibody reacts with Bovine, Dog, Human, Mouse, Rat.
Product Specifications
Synonyms
Lysine-specific demethylase 5C;1.14.11.-; Histone demethylase JARID1C; Jumonji/ARID domain-containing protein 1C; Protein SmcX; Protein Xe169; KDM5C; DXS1272E, JARID1C, SMCX, XE169
Gene Name
KDM5C
UniProt
P41229
Host
Mouse
Reactivity
Bovine, Dog, Human, Mouse, Rat
Immunogen
Purified recombinant human SmcX (C-terminus) protein fragments expressed in E.coli.
Clonality
Monoclonal
Tissue Specificity
Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. .
Applications
IF, WB
Purification
Affinity purification
Concentration
1 mg/ml
Form
Liquid
Function
Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity) . .
Molecular Weight
175720 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Lysine-specific demethylase 5C
Subcellular Location
Nucleus .
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