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Anti-MEKKK 4 MAP4K4 Antibody

Boster Bio Anti-MEKKK 4 MAP4K4 Antibody (Catalog # A02829) . Tested in WB, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.<br><br>Yao Z., J. Biol. Chem. 274:2118-2125(1999).<br>Wright J.H., Mol. Cell. Biol. 23:2068-2082(2003).<br>Ishikawa K., DNA Res. 5:169-176(1998).

Synonyms

Mitogen-activated protein kinase kinase kinase kinase 4;2.7.11.1; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Nck-interacting kinase; MAP4K4; HGK, KIAA0687, NIK

Gene Name

MAP4K4

UniProt

O95819

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from internal of human MEKKK 4.

Clonality

Polyclonal

Tissue Specificity

Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. .

Applications

WB, IF

Field of Research

MAPK Pathway, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. .

Molecular Weight

142101 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Mitogen-activated protein kinase kinase kinase kinase 4

Subcellular Location

Cytoplasm .

Frequently Asked Questions

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