Anti-MEKKK 4 MAP4K4 Antibody
Boster Bio Anti-MEKKK 4 MAP4K4 Antibody (Catalog # A02829) . Tested in WB, IF applications. This antibody reacts with Human, Mouse.
Product Specifications
Background
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.<br><br>Yao Z., J. Biol. Chem. 274:2118-2125(1999).<br>Wright J.H., Mol. Cell. Biol. 23:2068-2082(2003).<br>Ishikawa K., DNA Res. 5:169-176(1998).
Synonyms
Mitogen-activated protein kinase kinase kinase kinase 4;2.7.11.1; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Nck-interacting kinase; MAP4K4; HGK, KIAA0687, NIK
Gene Name
MAP4K4
UniProt
O95819
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from internal of human MEKKK 4.
Clonality
Polyclonal
Tissue Specificity
Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. .
Applications
WB, IF
Field of Research
MAPK Pathway, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Form
Liquid
Function
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. .
Molecular Weight
142101 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Mitogen-activated protein kinase kinase kinase kinase 4
Subcellular Location
Cytoplasm .
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