Anti-PIP5K PIKFYVE Antibody

The PI(3, 5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3, 5-bisphosphate (PtdIns(3, 5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3, 5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.<br><br>Ota T., Nat. Genet. 36:40-45(2004).<br>Sbrissa D., J. Biol. Chem. 277:6073-6079(2002).<br>Brill L.M., Anal. Chem. 76:2763-2772(2004).

1-phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase;2.7.1.150; FYVE finger-containing phosphoinositide kinase; PIKfyve; Phosphatidylinositol 3-phosphate 5-kinase type III; PIPkin-III; Type III PIP kinase; PIKFYVE; KIAA0981, PIP5K3

The PI (3,5) P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns (3,5) P2) . Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. .