Anti-Ephrin-B2 (Ab-330) EFNB2 Antibody

Ephrin-B2 encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a lycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. <br> <br> Chrencik JE, et al.( 2006) J Biol Chem;281(38):28185-28192. <br> Kertesz N, et al. (2006) Blood; 107(6):2330-2338. <br> Noren NK, et al. (2004) Proc Natl Acad Sci USA; 101(15):5583-5588.

Angiogenesis, Axonal Guidance Proteins, Cancer, Cardiovascular, Cell Type Marker, Growth and Development, Intracellular Signaling, Invasion/Microenvironment, Kinases, Neurology Process, Neuron Marker, Neuroscience, Neurotransmission, Receptors / Channels

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.