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Anti-HES7 HEXIM1 Antibody

Boster Bio Anti-HES7 HEXIM1 Antibody (Catalog # A02321-1) . Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.<br> <br> Kusuhara M., Biomed. Res. 20:273-279(1999).<br> Wittmann B.M., Cancer Res. 63:5151-5158(2003).<br> Ouchida R., Genes Cells 8:95-107(2003).

Synonyms

Protein HEXIM1; Cardiac lineage protein 1; Estrogen down-regulated gene 1 protein; Hexamethylene bis-acetamide-inducible protein 1; Menage a quatre protein 1; HEXIM1; CLP1, EDG1, HIS1, MAQ1

Gene Name

HEXIM1

UniProt

O94992

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from Internal of human HEXIM1.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. .

Applications

WB, IHC, IF

Field of Research

Cardiogenesis, Cardiovascular,2339, Co-Factors, Epigenetics and Nuclear Signaling, Hypertrophy, Transcription, Transcription Factors, Transcription Factors/Regulators

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. .

Molecular Weight

40623 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Protein HEXIM1

Subcellular Location

Nucleus . Cytoplasm . Binds alpha-importin and is mostly nuclear (PubMed:16362050) .

Frequently Asked Questions

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