Anti-TAF1/Kat4 Antibody

Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4.<br><br>Sekiguchi T., Mol. Cell. Biol. 11:3317-3325(1991).<br>Ruppert S., Nature 362:175-179(1993).<br>Nolte D., Proc. Natl. Acad. Sci. U.S.A. 100:10347-10352(2003).

Transcription initiation factor TFIID subunit 1;2.3.1.48;2.7.11.1; Cell cycle gene 1 protein; TBP-associated factor 250 kDa; p250; Transcription initiation factor TFIID 250 kDa subunit; TAF (II) 250; TAFII-250; TAFII250; TAF1; BA2R, CCG1, CCGS, TAF2A

Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA- binding activity. Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607) . Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300) . .