Anti-ZMY11 ZMYND11 Antibody

Boster Bio Anti-ZMY11 ZMYND11 Antibody (Catalog # A02092-1) . Tested in IHC applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) By similarity. Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.<br><br>Hateboer G., EMBO J. 14:3159-3169(1995).<br>Deloukas P., Nature 429:375-381(2004).<br>Matsuoka S., Science 316:1160-1166(2007).

Synonyms

Zinc finger MYND domain-containing protein 11; Adenovirus 5 E1A-binding protein; Bone morphogenetic protein receptor-associated molecule 1; Protein BS69; ZMYND11; BRAM1, BS69

Gene Name

ZMYND11

UniProt

Q15326

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from internal of human ZMY11.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. .

Applications

IHC

Field of Research

Antiviral Signaling, Cell Biology, Cell Cycle, Cell Cycle Inhibitors,2339, Epigenetics and Nuclear Signaling, Immune System Diseases, Immunology, Pol II Transcription, Polymerase Associated Factors, RNA Polymerase, Transcription, Transcription Factors

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Immunohistochemistry: 1:50~1:100

Form

Liquid

Function

Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity) . Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. .