Anti-MICU1/Cbara1 Monoclonal Antibody

Calcium uptake protein 1, mitochondrial; Atopy-related autoantigen CALC ; ara CALC ; Calcium-binding atopy-related autoantigen 1 ; Hom s 4 ; MICU1; CALC , CBARA1

Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988) . MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221) . Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221) . Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221) . Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319) . Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733) . .

Mitochondrion inner membrane ; Single- pass membrane protein . Mitochondrion intermembrane space . The topology is subject to discussion. According to some reports, localizes at the outer surface of the mitochondrion inner membrane (PubMed:20693986, PubMed:24332854) . According to another publication, forms a intramembrane hairpin loop without crossing the membrane (PubMed:23747253) . Recent studies rather suggest that it contains a transmembrane region that crosses the mitochondrial inner membrane, with the main part of the protein localized in the mitochondrial intermembrane space (PubMed:26387864, PubMed:26489515) . .