Anti-eNOS (Ab-1177) NOS3 Antibody

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. <br><br>Fulton, D. et al. (1999) Nature 399, 597-601. <br>Harris, M.B. et al. (2001) J. Biol. Chem. 276, 16587-16591. <br>Thomas, S.R. et al. (2002) J. Biol. Chem. 277, 6017-6024.

Cancer, Cancer Metabolism, Cardiovascular, Cell Biology, Metabolism, Metabolism Processes, Neuroscience, Neurotransmission, Oxidative Stress, Pathways and Processes, Platelets, Redox Metabolism, Response To Hypoxia, Vasculature

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.