Anti-BIM (Ab-69) BCL2L11 Antibody
Boster Bio Anti-BIM (Ab-69) BCL2L11 Antibody (Catalog # A01552-1) . Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-a1, isoform Bim-a2 and isoform Bim-a3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
<br><br>Fukazawa H, et al. (2004) Mol Cancer Ther ; 3(10): 1281-1288
<br>Luciano F, et al. (2003) Oncogene ; 22(43): 6785-6793
Synonyms
Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death; BCL2L11; BIM
Gene Name
BCL2L11
UniProt
O43521
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa.67~71 (P-A-S-P-G) derived from Human BIM.
Clonality
Polyclonal
Tissue Specificity
Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. .
Applications
WB, IHC
Field of Research
Alzheimer's Disease, Apoptosis, Apoptotic Markers, Associated Proteins, Cancer, Cell Biology, Cell Death, Immunology, Innate Immunity, Intracellular, Invasion/Microenvironment, Macrophage/Inflammation, MAPK Pathway, Metabolism, Metabolism Processes, Neurodegenerative Disease, Neurology Process, Neuroscience, Oncoproteins, Oncoproteins/Suppressors, Pathways and Processes, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/ml
Form
Liquid
Function
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. .
Molecular Weight
22171 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Bcl-2-like protein 11
Subcellular Location
Endomembrane system ; Peripheral membrane protein . Associated with intracytoplasmic membranes. .
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