Anti-p70 S6 Kinase (Ab-411) RPS6KB1 Antibody

Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation. <br> <br> Satoru Eguchi et al. (1999) J Biol Chem, Vol. 274: 36843-36851 <br> Papst PJ, et al. (1998) J Biol Chem. 273(24):15077-84. <br> Ulrike Krause et al. (2002) Eur. J. Biochem. 269: 3751-3759 c <br> Le, X.F, et al. (2003) Oncogene 22: 484

Cell Biology, Cell Cycle, Cell Cycle Inhibitors, DNA/RNA, DNA Damage Response, Epigenetics and Nuclear Signaling, Metabolism, Obesity, Protein Phosphorylation, Ribosome, Ser/Thr Kinases, Signal Transduction, Translation

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.