What is the catalog number for Anti-GDF-5 Antibody?

The catalog number for Anti-GDF-5 Antibody is A01356-1.

What sizes are available for Anti-GDF-5 Antibody?

Anti-GDF-5 Antibody is available in the following size(s): 100 µL.

Is Anti-GDF-5 Antibody in stock?

Anti-GDF-5 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-GDF-5 Antibody?

The safety data sheet for Anti-GDF-5 Antibody is available here: https://www.bosterbio.com/msds?sku=A01356-1.

Anti-GDF-5 Antibody

Boster Bio Anti-GDF-5 Antibody catalog # A01356-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Growth/differentiation factor 5; GDF-5; Bone morphogenetic protein 14; BMP-14; Cartilage-derived morphogenetic protein 1; CDMP-1; Lipopolysaccharide-associated protein 4; LAP-4; LPS-associated protein 4; Radotermin; GDF5; BMP14, CDMP1

Gene Name

GDF5

UniProt

P43026

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human GDF5. AA range:361-410

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level) . .

Applications

IHC, WB

Purification

The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.

Concentration

1 mg/mL

Form

Liquid

Function

Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592) . Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273) . Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity) . Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205) . .